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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: INPP5D All Species: 6.06
Human Site: S897 Identified Species: 13.33
UniProt: Q92835 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q92835 NP_001017915.1 1189 133292 S897 M K Q W E V T S R A P P C S G
Chimpanzee Pan troglodytes XP_526066 929 104074 M656 E I I N P N Y M G V G P F G P
Rhesus Macaque Macaca mulatta XP_001114794 1258 138636 S916 I Q E P R S G S R K P A F T E
Dog Lupus familis XP_542327 1264 138869 N922 S Q D P R S G N R K P A P A E
Cat Felis silvestris
Mouse Mus musculus Q9ES52 1191 133524 G900 M R Q W E P S G R V P A C G V
Rat Rattus norvegicus P97573 1190 133575 G899 M R Q W E P A G R V P A C G I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520934 1019 113512 A746 V S R T P M Q A L R V T G L S
Chicken Gallus gallus XP_422567 1182 133482 S896 K D S D Q L S S C T P T D I S
Frog Xenopus laevis Q6P4S2 1019 115278 Y746 T K S H T K F Y I E F H S P C
Zebra Danio Brachydanio rerio Q2I6J1 1266 140353 T900 S H D Y V K P T S S S S S R K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_789838 1327 148052 S902 E T A S A K I S K A K V C I E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 77.8 41.3 40.9 N.A. 87.8 87.8 N.A. 38.7 68.2 56.5 43.1 N.A. N.A. N.A. N.A. 31
Protein Similarity: 100 77.8 57.5 56.8 N.A. 92.1 92 N.A. 48.5 78.7 67.1 57.9 N.A. N.A. N.A. N.A. 47.3
P-Site Identity: 100 6.6 20 13.3 N.A. 46.6 46.6 N.A. 0 13.3 6.6 0 N.A. N.A. N.A. N.A. 20
P-Site Similarity: 100 6.6 46.6 33.3 N.A. 60 53.3 N.A. 26.6 33.3 6.6 20 N.A. N.A. N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 10 0 10 0 10 10 0 19 0 37 0 10 0 % A
% Cys: 0 0 0 0 0 0 0 0 10 0 0 0 37 0 10 % C
% Asp: 0 10 19 10 0 0 0 0 0 0 0 0 10 0 0 % D
% Glu: 19 0 10 0 28 0 0 0 0 10 0 0 0 0 28 % E
% Phe: 0 0 0 0 0 0 10 0 0 0 10 0 19 0 0 % F
% Gly: 0 0 0 0 0 0 19 19 10 0 10 0 10 28 10 % G
% His: 0 10 0 10 0 0 0 0 0 0 0 10 0 0 0 % H
% Ile: 10 10 10 0 0 0 10 0 10 0 0 0 0 19 10 % I
% Lys: 10 19 0 0 0 28 0 0 10 19 10 0 0 0 10 % K
% Leu: 0 0 0 0 0 10 0 0 10 0 0 0 0 10 0 % L
% Met: 28 0 0 0 0 10 0 10 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 10 0 10 0 10 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 19 19 19 10 0 0 0 55 19 10 10 10 % P
% Gln: 0 19 28 0 10 0 10 0 0 0 0 0 0 0 0 % Q
% Arg: 0 19 10 0 19 0 0 0 46 10 0 0 0 10 0 % R
% Ser: 19 10 19 10 0 19 19 37 10 10 10 10 19 10 19 % S
% Thr: 10 10 0 10 10 0 10 10 0 10 0 19 0 10 0 % T
% Val: 10 0 0 0 10 10 0 0 0 28 10 10 0 0 10 % V
% Trp: 0 0 0 28 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 10 0 0 10 10 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _